Boitsova O. New methodology for achieving adequacy of anesthesia and perioperative antistress protection

The dissertation presents a theoretical generalization and substantiates a new solution to the scientific and practical problem of improving the efficiency of patients’ with acute abdominal surgical pathology treatment by giving personalized energy-protective capacity to perioperative anesthetic management, based on the definition of oxygen consumption needs and the energy-structural status of patients.The research was performed on the results of the perioperative energy-structural status audit, its reserves, properties, and the effectiveness of autoregulation in 317 patients aged 18 to 86 years with acute abdominal pathology who underwent emergency and urgent surgery under sedoanalgesia, inhalation and intravenous anesthesia. By determining the level of neuron-specific enolase, brain damage was identified for all standard anesthesia methods. Supplementation of standard perioperative anesthetic management with energy-protective technologies decreases the risk of brain micro damage and significantly increases the perioperative energy-protective ability of anesthesia, which improves the results of treatment and thereby reduces the time of patients' stay in a hospital.