Budianska L. Effects of joint action of pharmaceutical substances in multi-compound systems based on model lipid membranes

The object of study: the effects of the membranotropic action of pharmaceutical substances in model lipid membranes. Objective: to establish the effects of the interaction of drugs in multi-compound systems based on model lipid membranes of various lipid composition. Research methods: differential scanning calorimetry, Fourier-IR spectroscopy, thermogravimetric analysis, optical microscopy, correlation analysis, quantum-chemical calculations. Scientific novelty: using the Freundlich adsorption model, the membranotropic action of water-soluble pharmaceutical substances was quantitatively characterized, the membranotropic action of the main active ingredient of the pharmaceutical preparation was shown to change depending on the chemical structure of the excipient, facilitation of passive transmembrane diffusion was shown for tilorone in the presence of dimethyl sulfoxide. Practical value: application in pharmacology and biotechnology in the development, testing, and optimization of pharmaceuticals composition.