Hurtovenko I. Comparative pharmacognostic study of some species of the genus Agastache (Agastache J.Clayton ex Gronov)

The thesis is devoted to pharmacognostic study of Agastache foeniculum (Pursch) Kuntze and Agastache urticifolia (Benth.) Kuntze, to the obtainment of the extracts from these species, development of quality control methods for herbal raw materials and extracts for the creation of new drugs with hepatoprotective, anti-inflammatory and antimicrobial activity. Generally, 1. By means of chromatographic methods, 112 compounds were identified in the raw material of A. foeniculum, including 15 classes of BAS, among which polyhydric alcohols, mono- and disaccharides. In A.urticifolia raw materials, 113 compounds were identified, which include 15 classes of BAS, among which, for the first time, are hydroxycinnamic acids, flavonoids, polyhydric alcohols, mono- and disaccharides, organic and fatty acids, amino acids, mineral elements. It has been established that the A. foeniculum extract exhibits antioxidant activity by its ability to suppress the auto-oxidation of adrenaline in vitro. The spectrum of antimicrobial activity of the A. foeniculum lipophilic extract was determined and this extract exhibited high antimicrobial activity against gram-positive microorganisms: Staphylococcus aureus, Bacillus subtilis, moderate activity against gram-negative microorganisms: Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris and fungi Candida albicans.