Redkina Y. Development of composition, technologies and researches of rectal suppositories of antiaggregate action with clopidogrelum

The thesis is dedicated to development of the scientifically grounded composition and technology of manufacture of the semisolid applicative dosage form with clopidogrel for rectal administration. On the base of complex investigations, it was scientifically grounded and experimentally confirmed the composition and technology of the rectal suppositories with clopidogrel on the hydrophilic base for prevention of atherothrombosis complications for patients with coronary stent and, also, as preventive measures for atherothrombosis for patients after myocardial infarction, ischemic stroke or with peripheral arteries’ diseases. Technology of compounding of the rectal suppositories with clopidogrel was proposed in form of informational letter of the Ministry of Health of Ukraine on «Pharmacy» problem, the results were implemented in practice of pharmacies of Cherkassy Regional Public Utilities Company «Pharmacia», Mykolaiv Regional Public Utilities Company «Pharmacia», Kyiv Public Utilities Company «Pharmacia», Private Joint-Stock Company «Liky Kirovogradshiny».