Pervak M. Patophysiological mechanisms of epileptic syndrome under conditions of transcranial direct current stimulation (experimental investigation)

It was established that anode – induced antiseizure effects are observed in 0,25- 2,0 h after tDCS, while cathode – induced antiseizure effects are registered appeared at the end of the first poststimulative hour and were clearly defined up to the 10th hour on the model of maximal electroshock seizures. For the first time the heightening of antiseizure effects of cerebellar tDCS with axitinib, which blocks tyrosine – kinase B activity, have been established. Thus, the latency of kindled seizures after axitinib administration (10,0 mg/kg) and cerebellar tDCS exceeded such one in the control by 2,5 times (p<0,05) and was significantly differ from corresponded data in groups with separate usage of tDCS and axitinib - by 30,2 %-47,4 %, (p<0,05). The combined usage of five trial of electric stimulation (100 Hz) of paleocerebellar lobule VI and axitinib (5,0 mg/kg), which were separately not effective, reduced the severity of PTZ-induced seizures by 38,7 % (p<0,05) when compared with the control. This fact points on the role of lobule VI as a mediator of antiseizure effects of cerebellar tDCS. It was established that cathode cerebellar tDCS reduced the power of alpha-band oscillations in the frontal brain cortex by 30,6 % (p<0,05), while anode tDCS reduced the power of both delta- and alpha- band power by 26,2 % (p<0,05) and by 38,6 % (p<0,05) correspondently. Anode tDCS also increased the power of beta- by 37,4 % (p<0,05) and gamma oscillations by 1,51 times (p<0,05).