Lomeiko O. Pathogenetic mechanisms of morpho-functional disorders of spermatozoa and their correction in men of reproductive age in a large industrial city (Zaporozhye and Zaporozhye region).

For the first time the peculiarities of sperm morphology and endocrine status in men working in hazardous production conditions were analyzed, an effective treatment complex was developed, taking into account the etiopathogenetic features of negative occupational influences (with predominance of high or low temperatures, stress loads and contacts ) in male infertility. To achieve the goal of the dissertation research, 187 men with infertility were examined, who were assigned to the main group, and 25 practically healthy men who were in the control group. Qualitative and quantitative indicators of spermograms (according to WHO criteria, 2010), indicators of endocrine status (total testosterone content in the calculation of free, luteinizing and follicle-stimulating hormones, estradiol, prolactin, blood cortisol and insulinula) were studied. For the first time, after examination of infertile men, it was determined that the complete "triad" of spermiological changes (according to WHO criteria, 2010) ˗ oligo-, astheno- and teratozoospermia, are formed under conditions of prolonged exposure to high temperatures or contact with agricultural fertilizers and poisons. other negative occupational influences cause mono- or bicomponent disorders: low temperatures form asthenozoospermia, prolonged stress - oligo- and asthenozoospermia. For the first time it was found that in the spermogram of infertile men, regardless of the type of negative occupational exposure, the changes are the same and characterized by a decrease in sperm count, impaired morphology and motor activity, while the severity of changes depends on the factor affecting the patient's body. during professional activities. The conducted diagnostic complex showed that in the conditions of influence of high and low temperatures there is a decrease in quantitative and qualitative indicators of spermogram, the lowest and most pronounced values are verified in the group exposed to high temperatures. The most "vulnerable" was sperm motility, in both groups asthenozoospermia was diagnosed with the worst values when exposed to low temperatures. An inverse correlation has been established between the number of motile sperm in the ejaculate and the duration of the professional history; r = -0,67 (p <0,05).