Melen Y. The effect of coronary artery stenting on the clinical course and remodeling of the left ventricle in patients with acute myocardial infarction with ST segment elevation and preserved left ventricular systolic function

The dissertation is devoted to the determination of the prognostic influence of PCI on the clinical course and features of LV remodeling in patients with STEMI and preserved LV systolic function in the near (stationary) and distant (12 months) periods. The features of structural remodeling of the left ventricle, the clinical course of the disease and the level of the marker of cardiovascular events - brain natriuretic peptide (NT-proBNP) in patients with STEMI, depending on the treatment strategy. Prognostic criteria influencing the level of NT-proBNP and types of left ventricular diastolic dysfunction are determined, namely: completeness of myocardial revascularization; the time of PCI from the moment of symptoms of MI; angiographic assessment of myocardial perfusion (MBG) after PCI and results according to the Zwolle Risk Score, which characterizes the safety of early discharge (<72 h) in this category of patients. It has been shown that PCI in patients with STEMI improves the clinical course of the disease, prevents severe disorders of diastolic function and pathological remodeling of the left ventricle and is accompanied by a lower level of NT-proBNP.