Grymailo V. Clinical and pathogenetic features of the development of cardiovascular disorders in patients with epilepsy

In the dissertation on the basis of complex researches the pathogenetic link between epilepsy and the formation of cardio-vascular pathology is identified. Clinical-neurophysiological features, biochemical markers, parameters of functioning of the autonomic and cardiovascular systems in patients with epilepsy are shown. The relationship between bioelectric activity of the brain according to EEG, functional activity of the autonomic nervous system according to the study of heart rate variability (HRV) and the appearance of cardiac disorders in patients with epilepsy. The effect of epilepsy on the autonomic regulation of cardiac activity has been clarified. The interrelation of cardiovascular system disorders and influence of changes of vegetative regulation on cardiac activity of patients with epilepsy and CP has been shown, which allowed to clarify the pathogenetic mechanisms of CP development in patients with epilepsy, in particular the influence of autonomic cardiac dysfunction and frequency of development. Peculiarities of lipid metabolism and development of atherosclerotic changes in this cohort of patients have been identified. The relationship of clinical features of the course of epilepsy, HRV and EEG with the frequency of development of KP is shown. ECG markers for the development of arrhythmias in patients with epilepsy have been identified, and HRV markers for approaching regular EN. Cardiovascular pathology has been shown to affect the course of epilepsy and impair the quality of life of patients with epilepsy (QOLIE-31). It has been proven that some anti-epileptic drugs can cause cardiovascular dysfunction and affect cardiovascular risk factors, and determine their effects on cardiovascular function in patients with epilepsy.