Kolesnyk O. Clinical and pathogenetic features and correction of hyperkinetic disorders in autonomic dysfunctions

The dissertation work was aimed at determining the state of the autonomic nervous system (ANS) and hyperkinetic disorders in cerebral angiodystonia, to improve diagnostics and to develop pathogenic principles of therapy. Actuality of the problem is marked by an increase in the prevalence of cerebrovascular diseases, the severity of various vegetative disorders, their pathogenetic heterogeneity, and poor results of treatment. 101 patients with cerebral angiodystonia were examined against the background of chronic cerebral ischemia (CСI) of compensated and subcompensated stages (n = 55) and the presence of autonomic dysfunctions (n = 46). The scientific novelty of the study is that on the basis of comprehensive clinical and experimental research pathological mechanisms of the formation of hyperkinetic disorders at the cerebral angiodystonia of different etiologies, as well as at different stages of the CCI are being assessed. Acceptable electrophysiological, hyperkinetic indices, as well as vegetative, psychoemotional testing data are obtained. The temporal experimental models of motor disorders that were reproduced by means of bilateral ischemia of the brain in rats were studied and characterised by its static-locomotor correlates. Experimental tests have been conducted on the effectiveness of treatment of cerebral ischemia with hyperkinetic syndrome, using antioxidants and nootropic drugs. The etiopathogenetic role of ANS in tremorogenesis is determined, as well as the degree of involvement in the pathological process at all levels. The effectiveness of the diagnostic algorithm for hyperkinetic disorders was studied. The electropharmacological complex with the use of antioxidant and nootropic drug in the treatment of vegetative and vascular dysfunctions with the presence of a motor component was substantiated, processed and implemented in the medical neurological practice.