Molodan D. The role of asymptomatic hyperuricemia in the development of endothelial dysfunction in patients with hypertension and obesity.

The dissertation is intended to optimize the diagnosis of violations of the functional state of vascular endothelium in patients with hypertension with obesity and asymptomatic hyperuricemia on the basis of the study of endocrine status of clinical and biochemical markers, changes in lipid and carbohydrate metabolism, the level of highly sensitive C-reactive protein and their interactions. It was found that the deterioration of the functional state of the endothelium with indicators below the reference - 312 ?mol / l. At 542.5 ?mol / L, the deterioration of endothelial function again becomes statistically significant. It has been proven that hyperuricemia is associated with insulin resistance, accompanied by an increase in the content of C-reactive protein in the blood, lipid peroxidation products, a decrease in the total antioxidant activity of the blood, and proatherogenic changes in the lipid profile. A model for assessing endothelium-dependent vasodilation without the use of an ultrasound test is proposed, including a combination of anthropometric, metabolic factors and the level of uric acid. Application of the proposed model will simplify the procedure for monitoring the function of the endothelium, eliminating the ultrasound examination of endothelium-dependent vasodilation, and reduce financial costs.