Onyshchuk T. The role of gender-age and neurohormonal factors – galectin-3 and aldosterone in the formation of the clinical profile and structural remodeling in young and middle-aged patients with hypertensive disease

The thesis is devoted to the study of the urgent problem of modern cardiology with regard to improving the prediction of the course of hypertensive disease (HD), stage II, in patients of young and middle age based on the study of the role of age-related and neurohumoral factors – galectin-3 and aldosterone in the formation of the clinical profile and structural remodeling of the heart and vessels. For the first time, galectin-3 has been shown to play a significant role in the development of disorders of the structural and functional state of the heart and carotid arteries in patients with HD stage II, while aldosterone plays a role in the circadian regulation of blood pressure. Clinical and instrumental factors have been identified that are associated with relatively high plasma levels of galectin-3 (> 2.4 ng / ml) and aldosterone (> 325 pg/ml) for this patient population. For the first time, the clinical profile of patients with different levels of galectin-3 and aldosterone was clarified and a prognostic scale for indirect determination of plasma levels of these neurohormones was developed. According to the results of the developed scale, there is a real possibility to determine groups of patients with relatively high levels of galectin-3 (> 2.4 ng/ml, 19 or more points on the scale) and aldosterone (> 325 pg/ml, 24 or more points on the scale) and identify prognostically unfavorable groups of patients. This approach provides an opportunity to improve the stratification of the course of HD stage II in young and middle aged patients, to select patients for more cardio- and vasoprotection, which will improve the quality of life and prognosis in these patients.