Schmidt P. Clinical and laboratory features of the course of chronic periodontitis among servicemen

The dissertation offers theoretical bases and scientific and practical solution of the urgent problem of modern dentistry connected with early diagnosis of severity of chronic apical periodontitis at military men in the absence of obvious clinical symptoms of an inflammation. Among servicemen with periapical infection in general and with complicated periodontitis (periostitis) in particular, ordinary soldiers predominate (p <0.05), which is (63.3 ± 2.9) % and (73.1 ± 3.4) %, respectively. The increase in CD3 + is above normal (82%) in both exacerbation and remission of apical periodontitis. The value of relative risk (RR) of the risk of exacerbation of chronic periapical infection in servicemen with the same CD3 + 59.4% was significant 1 [0.2; 6.6], p <0.05. A significant difference was found in the values of CD19 + cells between the groups with exacerbation (16.6 ± 1.9)% and remission by 6.6% (p = 0.019); this difference can be considered significant. High values (above 24.0%) of CD8 + were in (74.2 ± 4.6)% of patients with exacerbation of periodontitis and in (80.0 ± 7.3)% - with remission. Large indicators of the area occupied by elastase-positive material were almost the same both in the asymptomatic course of periodontitis and in the presence of pronounced clinical signs of exacerbation (13.62 ± 0.81)% and (11.70 ± 0.21)%, respectively. p> 0.05). Also in the absence of exacerbation in the inflammatory focus in some patients, the number of elastase-positive cells per conventional unit area was 20.35 ± 1.36, which did not differ significantly from the group with a pronounced exacerbation of chronic inflammation - 26.73 ± 1.36 (g > 0.05). Changes in the value of lysozyme in the oral fluid indicate that in servicemen with exacerbation of chronic apical periodontitis with clinical signs of acute periostitis on the day of hospitalization, the antibacterial activity of oral fluid is 1.8 times lower than in healthy soldiers. In servicemen without clinically pronounced signs of acute periodontitis - chronic inflammation in remission, on the day of hospitalization was expressed antibacterial activity of oral fluid - the value of lysozyme was 2.5 times higher than in the control (p <0,05). The value of MDA in exacerbation of periodontitis decreased from 1.36 times (1 day) to 1.1 times (7-8 days). The mean value of elastase in patients in remission was consistent with patients with exacerbation of chronic apical periodontitis.