Domakova N. Prophylaxis and treatment of complications at the preterm premature rupture of the amniotic membranes.

The dissertation is devoted to increase the effectiveness of prophylaxis of perinatal complications at the preterm premature rupture of the amniotic membranes on the basis of clinical, instrumental, laboratory and morphological researches, and also development of the improved algorithm for the management of conducting pregnancy and delivery. Tactics of women management with preterm premature rupture of amniotic membranes depends on the duration of pregnancy and the results of additional research methods - the content of placental proteins, as well as an informative assessment of the fetus, its reserve capacity and readiness for delivery. The use of our improved algorithm of treatment and prevention measures can reduce at 22-27.5 weeks of pregnancy the incidence of pathology of the central nervous system by 7.3% and intrauterine infection - by 16.8%; at 22-27.5 weeks of pregnancy - respiratory distress syndrome by 6.4%; pneumonia - 20.3% and intrauterine infection - by 4.3%; at 31-33.5 weeks of pregnancy - pneumonia by 10.1% and pathology of the central nervous system - by 2.7%, respectively.