Barchan G. Optimization of the prognostication for the course and prevention of recurrent respiratory infections in children

The research deals with an increase in the effectiveness of prognostication for the course and prevention of relapses of recurrent respiratory infections (RRI) in children. The main tasks of the research were as follows: study of the diagnostic value and prognostic significance of constitutional-biological (CBM) and visceral-functional (VFM) markers of undifferentiated connective tissue dysplasia (UCTD) in RRI with substantiation of an algorithm for assessing the risk of RRI on the basis of taking into account highly informative and prognostically valuable markers of UCTD. The research paper contains results of the study of the frequency, character and severity of general nonspecific adaptive responses (GNAR) as well as data concerning the state of the immune system (IS), particularly T, B and phagocytic chains in children with RRI depending upon the severity of manifestations of UCTD. Formulae of IS disorders in RRI in children with different degrees of severity of UCTD are substantiated and targets for correction of IS with assessment of the clinical efficiency of phytoneering multicomponent phytogenic drug by results of a prolonged outpatient-polyclinic monitoring of children are specified. The research isolated several syndromes for prognosticating RRI, namely: syndrome of dysplasia-dependent dysmorphia in (63.0 ± 5.0) % of children, visceral-functional syndrome in (28.3 ± 4.7) % of children and syndrome of kinetic disorders in (46.7 ± 5.2) % of children. The effectiveness in RRI is practically higher by 25.1 % versus the children having RRI combined with UCTD (respectively, 0.608 bits and 0.486 bits). A reliable decrease in the frequency of RRI episodes at the expense of a reduced share of prolonged (over 14 days) cases and an increase of the share of children with the duration of their remission over 6 months were revealed