Simbirova A. Peculiarities of topometric preparation for radiotherapy in stage I-II uterine cancer patients using in vivo dosimetry

Thesis for a candidate degree in medical sciences in specialty 14.01.23 "Radiation diagnostics and radiation therapy" - Kharkov Medical Academy of Postgraduate Education, Ministry of Health of Ukraine, Kharkov, 2021. Results of a study of 140 patients with uterine cancer, 125 of which with stage I disease (T1bNxM0) and 15 patients with stage II (T2NxM0) The most effective method of treatment of uterine cancer is considered to be surgery, after which, the second step is radiation therapy. The most important step in radiation therapy is rational dosimetric planning and regular in vivo dosimetry, which allows you to monitor the dose that is brought to the planned volume of the target and the risk organs directly during the radiation therapy. On the basis of own clinical researches the clinically new method of radiational preparation which use allows to correct in time the dosimetric plan of irradiation, increases accuracy of definition of the absorbed dose in irradiated volume, allows to avoid development of radiation reactions from critical bodies and unplanned breaks in treatment. It is proved that timely adjustment of the dosimetric plan of irradiation due to the use of dosimetry in vivo allows to reduce the frequency of radiation cystitis by 1.73 times, and radiation rectitis by 1.92 times. Significant influence of constitutional features of uterine cancer patients on deviations between the planned dose and results of dosimetry in vivo when using photon radiation on the Clinac 600 device is established. Practical recommendations on preradiations topometric preparation of patients with excess weight are given, which allows to level the difference between the planned and actually received dose. Key words: uterine cancer, topometric preparation, in vivo dosimetry, radiation toxicity.