The work is based on a retrospective analysis, an experimental study on female white rats and on a prospective study of early pregnancy in women with early gestational complications on the background of chronic gastritis. By means of a retrospective study, it was found that pregnant women with chronic gastritis have a statistically higher frequency of early gestosis (vomiting of pregnant women); (p = 0.006); - threats of abortion (p = 0.04), - involuntary miscarriage, (p <0.001). Analysis of the course of pregnancy between pregnant women of groups 1 and 2 showed that in group 1 diagnosed: vomiting of pregnant women in 29.3%, the threat of abortion in 60.3%, involuntary miscarriage in 5.2%, stillborn pregnancy - 5.2% .In group 2, respectively: 29.0%, 51.6%, 8.1% and 11.3%. Despite the absence of a significant difference in the frequency of gestational complications between pregnant women of groups 1 and 2, it was determined that the clinical course of early gestational complications is more severe in pregnant women of group 1 and depends on the presence of chronic gastritis in pregnant women that causes changes of acidity of stomach and depends on the availability of AB to. H.pylori, which is the cause of dyspeptic disorders in early pregnancy and leads to changes in the gastrointestinal motor function of the gastrointestinal tract. It was found that different combinations of clinical implications of early gestational complications and gastrointestinal dysfunction prevailed in pregnant women with gastritis: the risk of abortion and vomiting of pregnant women 3 times, the risk of abortion, vomiting of pregnant women and constipation 4.3 times, the risk of abortion and constipation in 1.6 times. In 1st group of pregnant women, mild vomiting was observed in 5.9% of patients, in the 2nd group of mild vomiting of pregnant women - 88.9%. In the group of pregnant women with chronic gastritis, the frequency of vomiting of medium severity pregnancy was 70.6%, and severe - 23.5%. In the group of pregnant women without chronic gastritis, the average and severe vomiting of pregnant women was 5.6%. When assessing the state of acidity, it was found that in group 1 of pregnant hyperacid states were 3.2 times more than in group 2. The frequency of hypoacid states in women of group 2 was twice as high. The level of normal acidity was observed in 11.8% of women of group 1 and 11.1% of pregnant women of group 2. AB to H.pylori was identified in 88.2% of pregnant women of group 1, in pregnant women of group 2 the presence of AB to H.pylori was identified in 27%. It was noted that the highest percentage of positive results for the presence of AB to HP had women with chronic gastritis and vomiting of pregnant women: with medium severity - 66.7%, and with severe - 26.7%. In the group of pregnant women without chronic gastritis AB to HP were observed in women with mild vomiting of pregnant women - 60.0%. When assessing the frequency of positive results for the presence of AB to HP, it was found that women with hyperacid type of gastritis and vomiting of pregnant women had the highest positive result and amounted to 53.3%. The dissertation contains a new approach to solving current problems of modern obstetrics - improving the quality of life, improving pregnancy by reducing the frequency of early gestational complications in pregnant women with chronic gastritis by determining the pathogenetic mechanisms of development and complications in early gestation. As a result of the conducted researches the main risk factors for the development of early gestational complications in pregnant women on the background of chronic gastritis were revealed. The study showed that the severity and duration of such early gestational complications, vomiting of pregnant women and the risk of abortion depends on the presence of a history of gastritis in pregnant women and the change in acidity and AB to H.pylori, which in turn causes a number of dyspeptic disorders that are factors that exacerbate the clinical implications of vomiting in pregnant women and the threat of abortion, affect the duration of these complications and the consequences of pregnancy, have a significant impact on the quality of life of pregnant women in the first trimester of pregnancy. Diagnosis of chronic gastritis at the pre-pregnancy stage, therapy aimed at eradication of H.pylori in case of detection of Helicobacter pylori associated gastritis will significantly improve the course of early pregnancy, reduce the number of cases of vomiting in medium severity and severe pregnant women, and reduce the frequency of dyspeptic disorders that in its turn will improve the clinical symptoms of early gestational complications.
