Piddubna O. Clinical features of nervous system lesion in chronic hemoblastosis

The study is based on a comprehensive examination of 86 patients with chronic hemoblastosis (CH) using clinical neurological, immunological, neurophysiological, neuroimaging, psychodiagnostic and statistical methods, a theoretical substantiation and a new solution of the actual scientific problem of modern neurology - improving the diagnosis and treatment of the central and peripheral nervous system lesion in patients with chronic lymphocytic leukemia, chronic myeloid leukemia and multiple myeloma. Comprehensive investigation of neurophysiological, neuroimaging and immunological features in patients with lesions of the nervous system in CH, depending on the duration of disease was carried out in a comparative aspect for the first time. First time the clinical and neurological features of the course of chronic lymphocytic leukemia, chronic myeloid leukemia and multiple myeloma were systematized. Was conducted a comprehensive qualitative neuropsychodiagnostic assessment of cognitive functions in patients with subsequent analysis of quality of life assessment in patients with CH, with the study of correlations of quality of life scales with neurophysiological and immunological parameters. On the basis of a comprehensive analysis of clinical and paraclinical parameters, the substantiation of α-lipoic acid in the complex treatment of patients with chronic hemoblastosis with secondary polyneuropathy was carried out.