A prospective randomized controlled clinical trial was conducted. The study included 123 patients aged 19 to 96 years (mean age 66.1±16.5 years, 50 men and 73 women) hospitalized in the intensive care unit (ICU). All patients were randomized to one of the groups: group I (Sorb group, Sorb. - Sorbitol, n = 32) - patients who received a starting intravenous infusion of 500 ml of a balanced polyionic solution with 6% sorbitol and 1.9% sodium lactate; Group II (Gel group, Gel. - Gelatin, n = 31) - patients who received a starting intravenous infusion of 500 ml of a colloidal solution of 4% modified liquid gelatin (succinylated gelatin) in a balanced polyionic solution (Ringer's acetate); Bal. - Balanced crystalloids, n = 29) - patients who received a starting intravenous infusion of 500 ml of a balanced polyionic solution (Ringer's acetate) with 0.07% L-malate, group IV (NS group, NS - Normal solution, control) (n = 31) - patients who received a starting intravenous infusion of 500 ml of 0.9% sodium chloride solution. The introduction of different types of infusion solutions was accompanied by a pronounced hemodynamic effect during the first 15 minutes. The greatest influence on hemodynamic parameters (MAP level, CO, and SVI) was exerted by infusion therapy using gelatin solution. According to the strength of the effect on the hemodynamics of the group can be distributed as follows: II (Gel)> I (Sorb)> III (Bal)> IV (NS). The study of oxygen delivery showed significantly better results in groups II (Gel), I (Sorb) compared to groups III (Bal), IV (NS). This advantage was significant (p<0.05). After the initial infusion in groups I, II, and III revealed significant increases in blood pH after 1 hour, respectively, p = 0.020, 0.012, and 0.014. In groups I and II found very significant increases in the level of partial pressure O2 of the central venous blood after 1 hour, respectively p = 0.002 and p<0.001. In groups I, II, and III, significant increases in BE levels were detected 1 hour after infusion, respectively p = 0.037, 0.011, and 0.011. In all groups there were significant increases in ScvO2 levels of central venous blood 1 hour later after infusion, especially in groups I and II were extremely pronounced changes, respectively p<0.001, p<0.001, p = 0.034, and 0.028. Against the background of infusion therapy, renal function did not change significantly (creatinine and GFR levels did not change in any groups 24 hours after infusion).
