Domres N. Clinical and paraclinical characteristics and treatment of spasticity in patients with multiple sclerosis.

The dissertation is devoted to the study of clinical-neurological, neuropsychological, neurofunctional, neuroimaging and neurophysiological features of spasticity in patients with MS in order to improve the diagnosing criteria of MS spasticity, identifying early indicators of spasticity and predictors of development of high spasticity, and treatment optimization. A comprehensive analysis of clinical and demographic data in 100 patients with MS with spasticity was performed. The assessment of mean and total spasticity in patients of different ages, sex, severity on the EDSS scale and type of disease with the definition of correlations. The influence of T25-FW and 9HPT, VAS, MFIS, EuroQol test results on the level of the total spasticity score was established. The main electrophysiological indicators of early manifestations of muscle spasticity of the upper and lower extremities have been determined. The relationship between the level of spasticity and the number and number of foci of demyelination in the brain and spinal cord according to MRI and predicted the factors of spasticity. The influence of antispastic therapy on clinical, electroneuromyographic and neurofunctional signs of spasticity were evaluated.