Petrenko O. Antidisbiotic prevention of experimental gastropathies

The thesis is devoted to the research of endogenous microbiota role in the development of gastropathies of different etiology, i. e. substantiation of the dysbiotic mechanism of these diseases pathogenesis. Experimental researches showed that at action of etiological factors the level of biochemical markers of inflammation always increases in a mucous membrane of rats’ stomach. It has been shown for the first time that the development of gastropathies by the mechanism of dysbiosis, judging by its degree increase, reduces the immune protection of the mucous membrane. For the first time it has been shown that experimental therapy of hepatogenic gastropathy (after administration of hydrazine sulfate) with combined antidisbiotics reduces the activity of the marker of inflammation of elastase in the gastric mucosa and tends to reduce urease levels. A new more effective gastroprotector phytogel "Quertulidone" with the content of the bioflavonoid quercetin, the prebiotic inulin and the immunomodulatory immudon has been developed. Permission was obtained from the Ministry of Health of Ukraine for its use, as well as for phytogel "Biotrit" and "Vinogradny" and for tablet forms of lequin and lekasil.