Omelchenko O. Functional MRI evaluation of the human brain neural networks under cerebral pathologies.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0423U100191

Thesis Registration Form

0423U100191.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

18-10-2023

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

The dissertation considers a comprehensive evaluation of human cerebral cortex neural networks in normal physiological conditions and cerebral pathology with fMRI. The evaluation of age, gender and methodical peculiarities of fMRI is still an actual task. The wider application of fMRI for diagnostic monitoring of neurorehabilitation in stroke, treatment of addictions, diagnosis of epileptogenic areas of the brain is being studied. The aim of the dissertation was fMRI evaluation of the interaction between movement control areas and the default mode network of the human brain in normal conditions and cerebral pathology. Obtained data showed that the default mode network of the human brain is functionally heterogeneous. When subjects perform finger movements, some areas of this network are deactivated (partially precuneus and posterior part of the cingulate gyrus), while others are activated (precuneus, posterior part of the cingulate gyrus, inferior parietal lobes, medial prefrontal cortex). Although, under the specified conditions, both of these systems are functionally interconnected. It has been shown that in both men and women, when performing motor tasks, areas of the primary sensorimotor cortex and the supplementary motor area of the contralateral hemisphere of the brain, as well as the ipsilateral hemisphere of the cerebellum, are activated. While in women, areas of the premotor cortex of the contralateral hemisphere of the brain and the contralateral hemisphere of the cerebellum are additionally activated, and in men - the activity of the left amygdala decreases. A potentially epileptogenic neural network was identified, which is manifested by the functional connectivity of areas of the temporal lobes, parahippocampal gyri, and left hippocampus. It has been demonstrated that with ischemic damage to the areas of the brain responsible for motor control, activation zones were found near foci with restricted diffusion of water protons, but not at the infarct region itself. It has been shown that therapeutic audio-visual stimulation leads to an increase in areas of cortical activation and a decrease in deactivation of the brain when performing finger movements. It has been established that with age, additional areas of the premotor cortex of both hemispheres of the brain are involved in the cerebral control of finger movements. The results of this study deepen the understanding of the mechanisms of involvement of different areas of the brain in the performance of manual movements in healthy subjects of different ages, of different sexes, and with cerebral pathologies. This will significantly improve the quality of preoperative mapping of brain functions during neurosurgical treatment. The results provide means to objectively predict and evaluate the course of neurorehabilitation in ischemic stroke and addiction treatment using the fMRI method. The obtained data can be the basis for creating new approaches in the diagnosis of temporal lobe epilepsy and localization of epileptogenic neural networks. fMRI assessment of brain activity made in the dissertation allows its further practical application in multiparametric brain MRI.

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Research papers

1. Omel’chenko A. N., Rozhkova Z. Z. Characteristics of fMRI patterns during the performance of hand and finger movements of different complexity / Neurophysiology – 2016 – №1 (48) – P.23-30. (Scopus)

2. Omel’chenko, A. N., Makarchuk N. E. fMRI Visualization of Functional Patterns of Neural Networks during the Performance of Cyclic Finger Movements: Age-Related Peculiarities / – Neurophysiology – 2017 – №5 (49) – P.372-383. (Scopus)

3. Омельченко О. М., Макарчук М. Ю. Активація кори головного мозку при виконанні рухового завдання у осіб з гострим порушенням мозкового кровообігу / ScienceRise: Biological Science» – 2018 – № 3 (12) – С.4-11.

4. Омельченко О. М., Макарчук М. Ю. Підвищена функціональна зв’язаність ділянок скроневої частки, як магнітно-резонансний маркер при скроневій епілепсії / Фізіологічний журнал – 2018 – №4 (64) – С.20-25. (Scopus)

5. Omelchenko O. M., Makarchuk M. Y., Bondarenko M. P., Bondarenko O. V. Partial deactivation of default-mode brain network during simple motor task execution / Фізіологічний журнал – 2022 – №2 (68) – С.3-8. (Scopus)

6. Stebliuk V., Striltsiv O., Omelchenko O., Yarovyi O. Combined psycho-physical neurofeedback therapy in the stimulant addiction treatment: clinical-psychological and EEG/fMRI study / Journal of Health Sciences – 2013 – Vol.3 (10) – P.325-336.

Omelchenko O., Rozhkova Z. Simultaneous but opposite functioning of task-positive (TPN) and task-negative (TNN) neural networks in human during simple motor task execution: model based fMRI ICA study / 2013, Prague, FENS Regional Meeting 2013, Sept 14, 2013.

Omelchenko O. Frequency spectrum of the default mode network (DMN) in the resting state (RS): characteristics by BOLD functional MRI (fMRI) / 2013, Kyiv, USN, III Scientific Conference of Young Physiologists, Oct 25, 2013.

Омельченко О. М. Особливості методик картування рухових функцій головного мозку методом функціональної МРТ / 2014, Київ, ІІ Національний Конгрес «Радіологія в Україні» з міжнародною участю, 27 березня 2014 / Променева діагностика, променева терапія – 2014 – №1-2 – С.130.

Omelchenko O., Rozhkova Z. fMRI brain mapping for visualization and quantitative characteristics of the activation/deactivation areas by motor tasks with various complicity / 2014, Київ, VI Конгрес Українського Товариства Нейронаук, 6 червня 2014.

Омельченко О. М., Рожкова З. З. Активація та деактивація первинної сенсомоторної ділянки (СМД) та поясної звивини (ПЗ) головного мозку людини при виконанні рухових завдань: дослідження методом функціональної МРТ (фМРТ) / ХІХ з’їзд Українського фізіологічного товариства ім. П. Г. Костюка з міжнародною участю, присвячений 90-річчю від дня народження П. Г. Костюка / Фізіологічний фурнал – 2014 – Т.60 – №3 (додаток) – С.46.

Омельченко О. М., Рожкова З. З. Визуализация некоторых узлов безусловной нервной сети (Default Mode Network) при выполнении заданий разной степени сложности / 2014, Київ, VII Міжнародна наукова конференція «Психофізіологічні і вісцеральні функції в нормі і патології», 8 жовтня 2014.

Omelchenko O., Rozhkova Z. Age-related peculiarities of the default mode and sensorimotor brain network interaction in human brain: fMRI study / 2015, Budapest, 15th Biannual Conference of the Hungarian Neuroscience Society, January 22, 2015.

Omelchenko O., Rozhkova Z., Stebliuk V., Yarovyi O., Rogozhyn V. Neurofeedback audio-visual stimulation (AVS) impact onto the brain networks interaction: fMRI study / 2015, Vienna, 27th European Congress of Radiology, March, 2015. DOI: 10.1594/ecr2015/C-1532

Omelchenko O., Rozhkova Z. Age-related peculiarities of the default mode (DMN) and sensorimotor (SMN) brain network interaction: fMRI study / 2015, Vienna, 27th European Congress of Radiology, March 5, 2015. DOI: 10.1594/ecr2015/C-1511

Omelchenko O., Rozhkova Z. Task-induced deactivation does not disrupt functional coupling of the default mode network during the movement / 2015, Toronto, 23rd ISMRM Annual Meeting, June 1, 2015.

Omelchenko O., Rozhkova Z., Makarchuk M. Gender differences in brain activation during movements: fMRI study / 2015, Kyiv, 5th Conference of Young Scientists, September 23, 2015. Book of abstracts, P.138.

Omelchenko O., Rozhkova Z., Bondar L., Myronyak L., Rogozhyn V. Altered brain activation in cortical-subcortical and pyramydal white matter stroke patients during hand motion: functional MRI study / 2016, Vienna, 28th European Congress of Radiology, March 3, 2016.

Omelchenko O., Rozhkova Z., Makarchuk M. Gender related peculiarities of amygdala deactivation during movements / 2016, Vienna, 28th European Congress of Radiology, March 4, 2016. DOI: 10.1594/ecr2016/C-1342

Omelchenko O., Makarchuk M. Localisation of the epileptogenic neural network by the resting state fMRI in patients with temporal lobe epilepsy / 2017, Vienna, 29th European Congress of Radiology, March 1, 2017, Abstract B-1394, P.S-481

Omelchenko O. Stroke-related brain plasticity of the human mirror-neuron system during audio-motor transformation: fMRI and DTI study / 2017, Vienna, 29th European Congress of Radiology, March 2, 2017, Abstract B-0354, P.S-257

Dykan I., Myroniak L., Lisovyi K., Gryshchak D., Zakomornyi O., Kobzar I., Makarchuk M., Omelchenko O. Dorsal and ventral pathways interaction for cognitive load evaluation in fMRI lie detection / 2021, Vienna, 33th European Congress of Radiology, March 3-7, 2021, Abstract RPS 711-7, P.278.

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