The work is devoted to development of an effective pathogenically validated method for the prevention of postpartum pyo-inflammatory complications in puerperants with gestational pyelonephritis. In postnatal state 82 womens with gestational pyelonephritis were examinеted. Only in 34,14% of women the symptoms of the kidney's infection were present, such as general weakness, low back pain, fever, that confirmed, that it was chronic process. In the majority of cases these patients had the pathological changes in the analisis of the blood and urine. It was established, that at the women, who had transferred gestational pyelonephritis during pregnancy, in postpartum the syndrome of endogenic intoxication was observed which lead to the dysfunction of the immunologic status of the organism and provoked the disturbance of the neutrophile's ultrastructure. New data about dynamics indexes of the endogenic intoxication, cell's and humoral brunches of immunity, morphologic structure of neutrophiles on the gr ound of enterosorbtion and immunocorrection in these women were determined. Patients with gestational pyelonephritis had the growth of the moleculas with middle mass, lowering quantity of T-cells due to T-lymphocytes subpopulations, decreasing of T-cell's activity, increasing of a relative contain of B-cells, serum levels of the immunoglobulins G, M, A and the damage of the neutrophiles, which lead to their dysfuction. Traditional prophylactics doesn't normalize foregoing indexes. The complex method of treatment gestational pyelonephritis in postpartum with the use of enterosorbent Silard-P and immunomodulator Echinacea purpurea is offered, high efficiency of which is testified theoretically and is practicaly confirmed. The ingradients of the prescribed therapy were one table-spoon-full of the enterosorbent Silard-P to 50 ml of water and 20 drops of the immunomodulator Echinacea purpurea infusion three times a day on an empty stomach. The duration of this treatment lasted 5-6 days. Any accesory phenomenous we re not observed. It was proved, that the oral usage of silicon sorbent with echinacea purpurea in complex preventive treatment of puerperants with gestational pyelonephritis had lead to the disappearance of the degree of the endogenic intoxication - the amount of moleculas with middle mass and the erythrocyte indexes of the endogenic intoxication normalization. As a result of this - the restoration balance between T-B- lymphocytes, the immunoglobulins G, M, A, circulating immune complexes and the morphological structure of neutrophiles were observed. Prescribe immunocorrection and enterosorbtion in the complex prophylactics of puerperants with gestational pyelonephritis reduced therefore the incidence of postpartum complications, p<0,001. Just so, only in 3 (7,50%) cases out of 40 puerperants with gestational pyelonephritis due to application of Silard-P and Echinacea purpurea the postnatal diseases were observed: the decrease of uterine involution in 1(2,50%) and the attach of pyelonephritis in 2 (5,0%) patients. In the case of traditional preventive therapy - in 12 (28,57%) puerperants such complications were present: 1 (2,38%)- lochiometra, 6 (14,29%) - the attach of pyelonephritis, 5 (11,90%) - the decrease of uterine involution. Prescribe prevention reduce therefore the amount of postpartum pyoinflammatory complications from 26,18% to 7,50%, p<0,001. In the case of traditional prophylactics in 1(2,38%) woman endometritis was present and in 10 (23,80%) - fever, but during complex prevention only in 3 (7,50%) cases the high temperature was observed. Prescribe preventive treatment reduce the patient's staying in the hospital to three days. The main outcomes of a recearch work were introduced in the practice of medical-prophylactic establishments of Ukraine.
