Koval'ova S. Synthesis, properties and biologocal activity of esters and amides of 2-oxoindolynecarbonic acid

The synthesis of iodinemethylates and methylbenzolsulfonates of 3,3-diaryl-2-oxoindolyne-1-, 5- and 7-carbonic acids basic esters and amides has been carried out. By means of the condensation of 2-oxoindolyne-3-glyoxylic acids with the amides as well 2-oxoindolynes with the esters of oxamynic acids according to Claisen method the synthesis of amides of 2-oxoindolyne-3-glyoxylic acids has been carried out. Influence on the first condensation of amine nature, nature of the solvent, molar ratio of reagents and temperature has been studied. The structure of the obtained substances has been confirmed by the data of element analysis,. IR-, PMR- and mass-spectra. Pharmacological screening of the obtained compounds has been carried out. For the profound pharmacological studying 4'-bromanylide 5-bromine-2-oxoindolyne-3-glyoxylic acids, which has high antidiphtherial and antiinflammatory activity has been selected.