Sukhotnyk R. The Pathogenic Role of Intracardial Renin-Angiotensin System in Mechanisms of Ischemic Lesions of the Myocardium

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U002659

Thesis Registration Form

0499U002659.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

22-10-1999

Specialized Academic Board

К58.601.01

Essay

We have established the succession of mechanisms of ischemic damage of the local renin-angiotensin system of the heart: ischemia - an increase of the intracardial content of angiotensin II - a decrease of tissue fermentative fibrinolytic activity of the heart - activation of the generation systems of oxygen radicals - activation of lipoperoxidation and peroxide modification of the myocardial proteins - disturbances of the electrolyte balance of cardiomyocytes. A complex use of inhibitors of the angiotensin-converting enzyme, AT1A-receptor blockers of the lozartan type and antioxidants to prevent ischemic-reperfusing lesions of the myocardium has been pathogenetically substantiated.

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