Shevchenko I. Syntesys‚ physical-chemical and biological рroperties of N- and S-substituted mono- аnd bicyclic azaheterocycles.

Preparative methods for synthesis of 5-thio-‚ 5- carboxyalcilthio-‚ 1‚2‚4-triasol-(3‚4b)-thiazole-3(2H)-onov derivatives have been worked out. On the basis of quantum-chemical estimates by Parizer-Parra-Pople method and prognosticated the direction of 1,2,4-triasoline-5-thiones alcylation reaction. The purposeful synthesis of biological active compounds among 3-mono and 3,4-disubstituted 1,2,4-triasoline-5-thiones have been performed. The structures of the synthesized compounds was confirmed by counter synthesis, elemental analysis data, UV-, IR-spectroscopy, mass-spectrometry and their individuality - by thin layer chromatography methods. Potasssium salt 3-(4-pyrydil)-1,2,4-triаsolil-5-metacaptoacetic acid having a high antiarrythmia activity was recomended for preclinical investigation.