274 pregnant women with normal current of pregnancy and fetoplacental failure (FPF) are surveyed which proceeded on a background of a various pathology, and also 259 newborn from these pregnant women. 38 healthy pregnant women and 31 healthy newborn (control); 42 pregnant women with fetoplacental failure and late gestosis, not receiving up to sorts of any treatment (arrived in hospital in delivery) and their 31 newborn; 52 pregnant women with fetoplacental failure and late gestosis, receiving treatment under the circuit without antioxidants and their 32 newborn (I group); 81 pregnant women with fetoplacental failure and late gestosis, receiving treatment under the circuit with inclusion antioxidants (?-tocopherol, ascorbic acid and siliborum) and their 75 newborn (II group); 30 pregnant women with fetoplacental failure and pyelonephritis and their 30 newborn; 31 pregnant women with fetoplacental failure and anemia and their 30 newborn and 30 newborn, transferred sharp intranatal hypoxia. In parents a nd placental blood were investigated concentration of products peroxide of oxidation lipids (POL): malonic dialdehyde (MDA), dienec conjugate (DC); ATP; activity of ferments: phospholipaase A, aldolase, phosphofructokinase (PFK), lactatedehydrogenase (LDG), thermostable alkaline phosphatase (TAF) and ?-hydroxybutyratedehydrogenase (?-HBDG) (all specified substances were investigated with the help photoelectrocolorimeter "КФК-2" and spectrophotometer "СФ-46"); the concentration phosphoinositidis (sharing the phosphoinositidis was investigated and the analysis of fractions carried out chromatographics on columns with ion-exchanging pitch). Estriols (on installation for radioimmunochemicals of researches "Гамма-800"). Were investigated morphofunctional parameters of erythrocytes and their form (at photographic registration of a morphological picture of blood on light microscope " Биолам Р-11 " at increase in 200 times). The diagnosis " fetoplacental failure " was established on the basis of the clinical data, re sults of laboratory researches in view of ultrasonic research intrabelly of a foetus and placenta, which was carried out on the device Sonoline SL-1 of firm " Siemens ". At FPF at the pregnant woman with anemia, pyelonephritis and at late gestosis of the pregnant women the increase of the contents of products POL, decrease of the contents ATP and change of activity ferments erythrocytes and plasma of blood is observed, these processes are accompanied by decrease physiological deformability of erythrocytes. At sharp intranatal hypoxia the foetus has significant changes of biochemical structure of blood, change of the form erythrocytes insignificant, obviously, in result short-term of influence of the specified biological - active substances. As a result of the carried out treatment with use antioxidants (vitamins Е and C, and also siliborum) in therapy of the pregnant women with fetoplacental failure by insufficiency, which proceeded on a background late gestosis of the pregnant women there was a normalization of clinical, microscopic and biochemical parameters at the mother and newborn, which received this treatment the specified changes were accompanied by improvement physiological deformability of erythrocytes. At the standard therapy of the specified pathology such improvement was not observed. The revealed biochemical and structural changes in blood at FPF, developed on a background late gestosis of the pregnant women, pyelonephritis and anemia, most likely, can be used as diagnostic criteria FPF and for the control of quality of realization of therapy.
