Baranovs'kyj S. Molecular basis of sequence- specific interactions of intercalative ligands with deoxyoligonucleotides of different length and secondary structure

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0502U000128

Thesis Registration Form

0502U000128.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

14-03-2002

Specialized Academic Board

Д 64.051.13

V.N. Karazin Kharkiv National University

Essay

Self - association of aromatic molecules - dyes, antibiotics and deoxyoligonucleotides of different nucleotide content, length and secondary structure, has been studied in aqueous solution using experimental NMR data and different models of molecular association. Complexation of typical intercalators with deoxyoligonucleotides has been investigated in aqueous solution. Distinctive features of sequence - specific bin ding of ligands with DNA and the spatial structures of different types of molecular complexes have been determined. The contributions of different types of reactions into summary enthalpy and entropy effects have been calculated. It has been shown that self - complementary deoxyhexa - and deoxyoctanucleotides are good model systems for investigation of thermodynamics of aromatic ligands binding with polymer DNA molecule. The obtained results may be used in the field of biophysics, molecular and medical physics.

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