Korzh O. Neurohumonal mechanisms of vasoregulation in the efficacy realization of chronic heart failure.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0502U000400

Applicant for

Specialization

  • 14.01.11 - Кардіологія

29-10-2002

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The object is chronic heart failure (CHF); the purpose - increase of efficiency of treatment CHF on the basis of studying a role of balance of vasoconstrictor and vasodilating factors of a vascular tone regulation in development of CHF, its values in realization of effects of pharmacotherapy and development on this basis of algorithms of optimization of pathogenetic therapy of CHF; methods - clinical and tool, biochemical and statistical; novelty - for the first time it is determined quantitative dysbalance of neurohumoral mechanisms of a vascular tone regulation in CHF as an exhaustion and insufficient activity of vasodilating factors on a background of vasoconstrictor hyperactivity, features of influence of various kinds of pharmacotherapy on clinical symptoms, haemodynamic parameters and activity of neurohumoral mechanisms in patients with ХСН are shown; the field is cardiology, clinical pharmacology.

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