Kovalyova A. Pharmakognostic investigation of plants of Fabaceae, Apiaceae, Convallariaceae, Asteraceae family and its prospects of use in medicine

The thesis is devoted to solve the problem of systematic purposeful search of plant resources of biological active substances and creation of medications. For the first time with the help of modern software technologies quantity fenetico-bionomics-taxonomical resource leading research of 81 species of Astragalus L. genus of NIS based on the analysis of 31 356 positive and negative states of 468 morphological indicators and ecotops using flavonoids and 1320 states of 60 indicators using cycloartans was made. For the first time phytochemical research of 11 species of astragals belonged to flora of Ukraine. Structures of 65 substations were marked out and determined. The structure of a new flavonoid - quercetinum-3- sophorozido-p-coumarat was determined. Activity of "Piflamin" substance as protector of hepatitus effect was determined. The effectiveness of cardiologic activity of new medicinal shape of tablets "Corglycon" was proved. The method for a definition of lipasotropic activity was worked out using express-method. 75 biological active substances and medications were investigated and inhibitors of lipase were determined. For the first time circadian activity of isolated lipase was revealed. The technology and analytical-scientific documentation of original medicine "Piflаmin" (substance and tablets) recommended for the registration and new medicine form of "Corglykon" (tablets) is inserted into production process were worked out.