Avdyeyeva L. Impruvement of the system of microbiologycal monitoring for nosocomial infection from newborns

Object of the research: nosocomial infection from newborns.Purpose of the research: to improvement the effection of nosocomial infections profilactic by means of creation of modern system of microbiologycal monitoring for this infections and development of new drug with large spectrum of antimicrobial activity.Methods of the research: microbiological, epidemiological, statistical.Theoretical and practical results: To proved the necessity of introduction of active microbiological monitoring into obstetric and neonatological hospitals, use of data of permanent monitoring for colonization agents, infection agents, their antibiotic resistance for selection of drugs for empiritic antibiotic therapy, use of analysis of profile of antibiotic resistance for estimate at hospital strains of microorganisms, determine of minimum inhibition and minimum bactericidal concentrations of Vancomicine for enterococcal in vitro, use new drug of Vosurel for elaboration of national drug with wide spectrum of antimicrobial activity. Novelty: For the first time system of active microbiologycal monitoring for nosocomial infections, including its computer version, were development. Was proved , that in this time take place to change of domination strains of newborns colonisation opportunic microorganisms. The domination strains of infection agents was determined. It was demonstrate differ of levels and profiles of antibiotic resistance of opportunic microorganisms strains, isolation from newborns in different profile hospitals, of some objects these hospitals, and opportunic patients. The necessity for use of analysis of antibiotic's profiles for reveal hospital strains. In first pick out vancomicine tolerans strains of enterococcal. It was show necessity of well grounded approach to prescription of intrusive methods of treatment. To proved the necessity of bacteriologycal investigation only epidemic important objects of hospitals. The new drug with wide spectrum of antimicrobial activity was work out. Degree of introduction: The results of the research introduc into 2 Instractions of Ukrainian Ministry of Heals.Sphere of application: Medicine, epidemiology.