Lunova G. T-helper immunity link role in kidney allotransplant rejection of man

The dissertation presents the optimization ways of kidney allograft rejection diagnostics based on studying recipients" peculiarities of T-lymphocyte-helpers type I and II functional activity in accordance with their producing a number of mediator-interleukines (IL-2, IL-10, IL-4, -interferon ( -INF). 149 recipients have been examined and analysed, 54 of which have primarily undergone transplantation, 12 - have undergone secondary allograft transplantation. 2804 immunological examinations of recipients have been performed, 2390 experiments have been carried out in vitro. The order of mediator production in recipients prior and after kidney transplantation taking into account the peculiarities of posttransplantation period, basing on which the algorithm of immune monitoring was developed. It has been shown that one of the main conditions of direct recipients peripheral blood T-helper immunomodulation is the individualization of immune-suppressive therapy protocols. Experimental data on examining interaction between immunosuppressive drugs (sundimmun-neoral, сell-cept, dexamethazone, prograf) have been analysed for the functional activity of immunecompetent cells. The experiments have been analysed in accordance with median effect equation, due to, which interaction factors have been determined, which characterize synergistic, additive and antagonistic interaction of immunesuppressive drugs. As a result of the research a new approach to immune-suppressive combinations and their dozes has been forend.