Marchenko S. Electrical and calcium signalling in the endothelium of intact blood vessels

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0504U000265

Applicant for

Specialization

  • 03.00.02 - Біофізика

06-04-2004

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

Еlectrical and calcium signalling have been studied in the endothelium in situ. Endothelial cells are connected with each other and with smooth muscle cells by effective electrical contacts. Endothelium-dependent vasodilators evoke а biphasic electrical response of hyperpolarization followed by depolarization. New calcium channels sensitive to the direction of mechanical stimuli have been recorded in the membrane of endothelial cells.

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