Malakhov V. The cell-membrane aspects of pathogenesis, treatment and preventive measures of initial stages of chronic cerebrovascular disease.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0504U000621

Thesis Registration Form

0504U000621.pdf

Applicant for

Malakhov Vladimir Aleksandrovich

Specialization

14.01.15 - Нервові хвороби

Date of defense

27-10-2004

Specialized Academic Board

Д.64.609.01

Essay

The dissertation contains information about structure and functial characteristics of erythrocyte membranes, cyclic nucleotid system, hemodynamic and microcirculation in the pathogenesis of initial stages of chronic cerebrovascular disease (initial forms of cerebrovascular deficiency and initial discirculatory encephalopathy). On the basis of complex investigations microcirculation ischemic-hypoperfusion disturbances, endothelial dysfunction by correlation NO/endothelin-1, levels of factor tumor necrosis alpha have been revealed. Disturbances of cell-membrane homeostasis are characterized by changes in c-AMP/c-GMP index, lipid peroxidation and cholesterosis of erythrocyte membranes, transport of Na+, K+, Ca2+, correlation of ATP and 2,3-DPG, lowering activity of glutation enzymes, changes of erythrocyte structure.

Thesis supervisor

Voloshin Petro Vlasovich

Official opponents

Міщенко Т. С.
Зозуля І. С.
Грицай Н. М.

Files

Диссертация_Малахова 2.doc

автореферат-best 2.doc

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