Ostrovska G. Primary mechanisms of membrane modulating action of bioregulators of natural and synthetic origine

The features of interaction of bioregulators with model membranes of different composition are investigated. It was displaied, that the studied substances are capable to interact with a lipide matrix of membranes with different efficiency without precursor involving of specific protein receptors. The efficiency of these processes depends on electrostatic and hydrophobic interpaсtions. The peptide-lipide interactions are modulated by the contents of optical isomers of aminoacidic residues in their moleculas, by ionic composition and ionic strength of a subphase. It is not revealed direct relation of membrane-tropic properties of the regulator peptides from length of their molecula. The role of a lipide phase in selection of a subtype of a receptor at peptide-membrane in-teraction is explained. The leading role in a display of membrane tropic properties of investigated bioregulators belongs to the phospholipids, whereas the proteins and cholesterol reduce intensity of their incorporation. The high membrane-tropic activity for a series of hepa-toprotective phytomedicine is established and its parameters are described. The relation of changes of this activity to features of phy-tomedicine obtaining is displayed. It can be applied by further search of natural membrane stabilizers. It is offered the scheme of the mecha-nism of realization of bioregulators effects with assistance of membrane lipide matrix.