Gordiyenko O. Mechanisms of passive permeability for non-electrolytes and spherical index of human erythrocytes.

Object of examination -the mechanisms of transmembrane mass-transfer in human erythrocytes, the dispersion of biophysical parameters of cells in a population, the temperature effect on a structurally and functional state of erythrocyte membranes. The purpose of work - the development of a new methods for determination of passive permeability coefficients and erythrocyte distribution for spherical index. Research techniques - thermodynamics of irreversible processes, theory of elasticity of thin shells at terminating strains, theory of casual processes, hydrodynamics, integration of singular equations with small parameter, Мy-theory of light scattering, method of small angle light scattering. For the first time the formula for entropy production in the system of selectively permeable membrane - polycomponent solution is obtained with consideration of equations of motion of solution's separate components. The derived correlation between biomembranes' standard transport characteristics and coefficients of friction between separate components of system in the case of closed selectively permeable moving membrane of random shape. There is developed a representation for physical mechanism of hypotonic haemolysis in permeable or non-permeable substances solutions and the physical and mathematical model of this process in both cases. The methods for determining the passive permeability of erythrocyte membranes for non-electrolytes and density of erythrocytes distribution by spherical index are elaborated. The erythrocytes permeability coefficients for series of non-electrolytes are determined and the mechanisms of their permeation are investigated. The erythrocytes distribution by spherical index in populations is studied. The coefficient of thermal expansion of human erythrocyte membrane was determined. Sphere of use - theoretical and applied biophysics, medicine.