Litovchenko T. The character of metabolic discharges and substantiation of principles pathogenetical ther-apy

3. Object of the study: pathogenetical mechanisms of epilepsy. Purpose of the study: to develop and to prove the concept of membrane-molecular mechanisms of epilepsy and optimum tactics of neuroprotective therapy on the basis of complex research of pathogenetical ultra structural and metabolic mechanisms of development and current of disease. Methods of the study: clinical, clinical-instrumental, neuroimaging, biochemical, biophysical, histological, experimental and statistical methods. Practical significance: on the basis of the carried out researches the features of neurophysiology, hemodynamics and morphology of epilepsy were specified depending on clinical current of disease. The basic biochemical parameters were determined and introduced into clinical practice which define the neuronal damage at stages of development of disease, influence weight of current and forecast of epilepsy. The validity and efficiency of application of melatonin was proved for the epileptic patients. The necessity of correction of microcirculation infringements at the epileptic patients was shown. The reasonable circuit of vitamins therapy was developed. As a result of clinical-experimental researches is developed and tactics of neuroprotective therapy of the epileptic patients is reasonable, the optimum medical circuits are offered depending on clinical current of disease, the necessity of differential neu-roprotective therapy is proved. Novelty of the obtained results: The concept of membrane-molecular mechanisms of epilepsy and optimum tactics neuroprotective of therapy was developed and substantiation. Complex study of a number of metabolic parts in epilepsy was carried out at the first time and their connection with clinical current of disease, neurophysiological and hemodynamical discharges, structural and ultra structural changes of brain was revealed. Dynamics and role of microcirculation discharges was investigated for the first time, their correlation with biochemical changes is established. The role of the free-radical pathology in damage of cell structures in epilepsy were determined and specified, condition of non-enzyme anti-oxidative system and vitamin balance, depending on clinical features of disease. Epileptogenic role of the increasing generation of oxide nitrogen was proved and connection of increase of oxide nitrogen with other biochemical parameters, morphological and clinical-functional changes in epilepsy. The role of melatonin in epilepsy was proved for the first time and its using in complex treatment is reasonable. The basic ultra-structural attributes of neurons damage were established in epilepsy. The general concept of neuroprotective therapy and optimum medical tactics of epilepsy were offered and reasonabled. Introduction: the results of researches are introduced into clinical-diagnostic process in neurological and psychiatric departments of the Central Clinical Hospital (Kharkiv); Kharkiv City Clinical Psy-chiatric Hospital - 15; Kharkov Regional Psychiatric Hospital; Kiev City PsychoneurologicalHospital - 1 (TDSC "Epilepsy"); Institute of Neurology, Psychiatry and Narcology AMS of Ukraine; Kharkov Regional Clinical Hospital; Lugansk Regional Clinical Hospital. The theoretical ideas and practical recommendations of the research are used in pedagogical process on the department of neurology and child neurology and department of psychotherapy of Kharkiv Medical Academy of Postgraduate Education, department of his-tology, cytology and embryology of Khirkv State Medical Univer-sity, department of neurology of the Lviv National Medical Univer-sity, department of neurology of Lugansk State Medical University. Sphere of application: medicine, neurology.