Khvorost O. The Pharmacognostic Study of Betulales Order Plants and Creation of New Biologically Active Substances with Different Action Direction

The thesis is devoted to the solution of the problem of creating new biologically active substances with an actual direction of the biological action by the systemic purposeful pharmacognostic research of the plants of Betulales order (genus of Betula and Alnus, Betulaceae family, and genus of Corylus, Carpinus and Ostrya, Corylaceae family). For the first time in Ukraine a complex comparative pharmacognostic study of 57 types of the species mentioned above has been performed on the basis of determination of a number of numeric values the most promising ones have been chosen for further research. The chemical composition of the plants and substances has been studied, a quantitative content of a number of BAS groups in Betulales order plants. The standardization of the biological action aspects has shown a perspectiveness of developing medications of the basis of the substances obtained. An antioxidant, anti-ulcerative, anti-inflammatory, immunomodulating action of altan included in the composition oftablets and the ointment and cardioprotective action of elgacin have been proven. For the first time the common scheme for the complex processing of fruits of alnus glutinosa and alnus incana has been offered, it combines the improved technology for obtaining altan-substance and technology for obtaining elgacin-substance. The launching regulations and analytical and normative documentation have been worked out altan has been introduced in production by a new technology. The projects of the technological regulations for obtaining dense extracts from Betula verrucosa leaves and Alnus glutinosa bark have been developed. 8 projects and analytical and normative documentation (three are for the raw material and 5 are for substances) have been worked out. 1. 6156