Klymenko S. Molecular biology of substrate cells and multidrug resistance mechanisms in acute leukemia patients suffered from the Chornobyl accident

The dissertation is devoted to analysis of treatment results, clinical, hematological, citogenetic, molecular-biological features, multidrug resistance determinants of acute leukemia in persons exposed to ionizing radiation due to the Chornobyl accident. The study results allowed to make a general conclusion and to suggest a new solution of the scientific problem relating to treatment optimization of radiation-associated acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The priority data was found concerning the tumorigenesis, phenotype of leukemia cells, and clinical course of radiation-associated acute leukemia. The strategy of AML and ALL treatment in clean-up workers and inhabitants of Ukrainian territories with high contamination from radionuclide fallout was developed as well.