Lazarenko L. The role of interferon system in papillomavirus infection pathogenesis

The dissertation is devoted to studying of a role of interferon system in immunopathogenesis process at papillomaviruses infection and cervix uteri neoplastic diseases associated with it (benign processes, cervical intraneoplasia and preinvasive cancer). It is established, that the increasing of a degree of diseases is accompanied with deep suppression of alfa- and gama-interferonogenesis. It is combined with a low spontaneous synthesis of this cytokine by peripheral blood cells and background level of interferon serum and associated with human papillomaviruses of high oncogenic risk types.It was observed the correlation of interferon production and other parameters of immune system. At cervix uteri papillomaviruses infection it was impaired the production of inflammatory cytokine - tumour necrosis factor-alfa and also the parameters of humoral and cellular immunity. The level of tumour necrosis factor-alfa receptor I (factor p55) in blood serum was increased at recidive diseases.The expediency of useof interferon preparations or interferon's inducers in complex treatment of patients has been proved. Use in complex treatment of the recombinant interferons- alfa2 preparations or cyklopheron has led the interferonogenesis processes and other parameters immune system normalization, that was accompanied by raise of clinical efficiency of therapy.