coronary artery disease and hypertension disease. Purpose of the research: to improve the diagnosis and prognosis of CHF by means of determining primary and secondary mecha-nisms of CHF progress, to study the influence of the dynamics of clinical, hemodynamic and humoral indices on the influence and death of the patients. Methods of investigation: general clinical, clinical laboratory, biochemical, and spectrofluorometric, enzyme, spectropho-tometric, immunoenzyme, instrumental, statistical. Theoretical and practical results: Threshold indices of hemody-namic and neurohumoral changes characteristic for CHF of vari-ous severity which allow the physician to make long-term progno-sis of the treatment efficacy were determined. Compensation norms of homeostasis parameters in CHF, which considerably dif-fered from the population values and allowed individualizing the correction of metabolic disorders in the patients were established. The most informative parameters of hemodynamics and organism homeostasis for any of the investigated functional class of CHF, which improve the quality of diagnosis of CHF FC, were distin-guished. The differences in the informativity of the parameters of hemodynamics and homeostasis in CHF were determined for di-agnosis and prognosis of transition to more severe FC of CHF, which allows to improve not only the accuracy of FC diagnosis but also CHF therapy. Specific features and informativity of hemodynamic parameters at various types of myocardium remodeling which allow to use them for monitoring of the treatment efficacy depending on the variant of LVH was determined. Algorithms of favorable and unfavorable prognosis of survival for class 2 CHF and class 3-4 CHF accord-ing to clinical history, hemodynamic and neurohumoral indices were worked out. Novelty: Specific hierarchical structure of pathogenetic compo-nents of hemodynamics was established for any of the investigated functional class of heart failure was established. It was determined that hemodynamic disorders which aggravateCHF FC did not coincide with pathogenetic factors of the previously formed more severe CHF FC, which was used fr diversification of CHF FC di-agnosis and its transition to more severe functional class. For the first time, qualitative evaluation of the contribution of primary and secondary mechanisms of humoral disorders to CHF pathogenesis was done. It was proven that disorders of homeosta-sis in CHF occur due to both primary and secondary mechanisms of pathogenesis. The hierarchy of a wide range of humoral ho-meostasis parameters in forming CHF severity was established. The highest places are occupied by the system of intracellular transportation of calcium, endothelin-1, noradrenalin and aldos-terone. It was revealed that impairments of free-radical processes play an important role in CHF development but do not influence CHF severity. The performed quantitative evaluation proved that of all indices of inflammation, which were studied, IL, AGI, MMM, TNF, IL-1, IL-4, IL-6, the most important role in CHF se-verity is played by TNF. For the first time, systemic analysis was used to determine the regulations of hemodynamic system func-tion in CHF depending on the type of left ventricle remodeling. The markers of CHF course prognosis and lethal outcomes were determined. A group of patients with cardiac cachexia was inves-tigated, the scheme of cardiac cachexia pathogenesis was sug-gested. Degree of introduction: The findings of the research were intro-duced into the clinical practice of specialized departments: Re-gional Clinical Hospital (Kharkiv), Institute of Therapy named after academician L. Malaya (Kharkiv), Kharkiv City Hospitals No. 17, 18, 227, Merefa CCH, Chuguev CCH, Balakleya CCH, Pervomaysk CCH, which was proved by the acts on introduction. Area of application: medicine, cardiology.
