Sivolob A. Molecular mechanisms of chromatin structural dynamics

. Experimental and theoretical results are presented on the mechanisms of the DNA-protein interactions in chromatin and the nucleosome and chromatin conforma-tional dynamics that depends on the DNA topological properties. Several structural states, which are realized at physiological conditions depending on the circular DNA supercoiling, are described for the nucleosome and other histone-DNA complexes. According to the results ob-tained DNA overall flexibility, along with essential DNA compaction, increases considerably upon chromatin par-ticles formation. Such a flexibility allows to achieve a selective activation of some genome regions provided that overall high level of DNA compaction is preserved in the cell nucleus.