Bojchenko P. The significance of cytomegalovirus infection for the development of somatic pathology in remote period after Chornobyl catastrophe

Thesis is devoted to evaluation of significance of cytomegalovirus (CMV) infection for forming and realization of somatic pathology in persons suffered due to Chornobyl NPP catastrophe and proposing methods for diagnosis and therapy of CMV reactivation to improve health state of suffered contingents.On the basis of observation of 2162 persons, divided on different groups of Chornobyl NPP catastrophe sufferers and a control group of persons without direct exposure to ionizing radiation, it was established that the frequency of serum anti-CMV IgG antibodies in clean-up workers (CW) (79.16%), convalescents of acute radiation sickness (ARS) (85,59%), NPP workers (78.12%) was higher than in control (69.20%) (p<0.05). The correlation between titres of anti-CMV antibodies and dose of irradiation was revealed among ARS convalescents (r = 0.3244; p = 0.028). The frequency of anti-CMV antibodies was higher in CW of 1986-1987 than in CW of later period. The increasing of CMV-seropositivity was caused by CMV reactivation. ELISA methods were prefered for diagnostics of CMV reactivation than polimerase chain reaction in CW patients. The frequency of anti-CMV antibodies was higher in patients with diseases of gastrointestinal tract, respiratory system, artrithis, diabetes mellitus, lymphadenopathy, hematological nontumor disorders, and the presence of anti-CMV antibodies was associated with negative prognostic parameters of these diseases. The risk of stable increasing of serum aminotransferase activity and enlargement of liver was raised in patients with simultaneous presence of anti-CMV antibodies and antibodies to hepatitis C virus. The indications for antivirus therapy in patients suffered due to Chornobyl NPP catastrophe were developed. Interferonogenesis' inducers were effective in the treatment of CMV reactivation. A test for detection of individual sensitivity of patients to interferonogenesis' inductors was proposed.