Kogan B. Diagnostics and treatment of rosacea, demodicosis and perioral dermatitis considering common factors of their development, pathogenesis and peculiarities of the dermatoses' clinical course.

The dissertation is devoted to theoretical summarizing and new solution of the scientific problem regarding increase of effectiveness of diagnostics, treatment and prevention of relapses of rosacea, demodicosis and perioral dermatitis, taking into consideration similar and different factors and mechanisms of etiology, pathogenesis and peculiarities of clinical course of these dermatoses. Common etiological agents and mechanisms of the onset and development of rosacea, demodicosis and perioral dermatitis have been defined. An important role among them belongs to invasion and pathogenic action of the mites Demodex folliculorum and Demodex brevis. Considering results of the studies of Demodex folliculorum and Demodex brevis mites' morphological and functional peculiarities it has been determined that their parasitism specialization is caused by significant reduction and substitution of organs and functions and also by some interdependent relations with the host - host, topical, gender, age and seasonal specificity. Role of a vascular component in pathogenesis of rosacea, demodicosis and perioral dermatitis at the local and systemic level has been determined as well as disorders of sexual hormones balance (androgens, estrogens) in patients. An improved complex program of treatment of rosacea, demodicosis and perioral dermatitis has been worked out. It suggests some measures directed at eradication of demodicidae mites and removal of other possible factors of development of these dermatoses and also individualized consideration of the peculiar clinical course of an inflammatory process and presence of concomitant pathology in different organs and systems. An original method of rosacea, demodicosis and perioral dermatitis relapses prevention has been developed. It considers seasonal specificity, inherent for demodicidae mites, and some dependence of their biological cycle on sexual hormones balance in the host body. It also suggests therapy which allows to achieve complete eradication of these parasites.