Doroshenko V. Kliniko-pathogenetic features of modern diphtheria at children

Dissertation is devoted to the actual problem of increasing the efficiency of diagnostics, differential diagnostics and nosotropic treatment of diphtherial infection at children. It is estimated that toxic cultures of C.diphtheriae have specific only for them peptid with molecular mass of 17 kD. Direct dependence was found out between the level of ecsotoxin in serum of blood and the difficulty of diphtheria, and also the difficulty of diphtherial myocarditis. The presence of C.diphtheriae in nouse and throat of children causes the increase of products of SIgA. It is estimated that the level of antibacterium antibodies in serum of blood depends on the type of infectious process and of the degree of the difficulty of illness and term of inspection. It is estimated that at all forms of diphtheria children have the changes of quantitative and qualitative parameters of thrombocytes, red bloody bodies and their functional activity, and also violation in the systems of rolling up and fibrinolysis of blood. The state of central hemodynamics at a diphtherial infection at children is predefined by the degree of difficulty of disease, and also presence and difficulty of diphtherial myocarditis. Effective method of kardiometabolitic therapy of diphtherial myocarditises at children was tested and offered by setting mildronat and method by intravenous low intensive laser radiation of blood in complex therapy of heavy forms of diphtheria.