Nikonenko A. Role of adhesion molecules in the mechanisms of synaptic plasticity

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0507U000151

Applicant for

Specialization

  • 03.00.02 - Біофізика

06-02-2007

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

Thesis deals with the study of adhesion molecules’ role in the mechanisms of adaptive changes of inhibitory and excitatory synapses in hippocampus. It was shown that molecules belonging to immunoglobuline family as well as extracellular matrix molecule tenascin-R are important factors in molecular mechanisms determining formation and maintenance of normal synaptic structure and function. The conclusion was made that adhesion molecules play an important role in synaptic plasticity phenomena.

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