Kutcher O. Role of genetic factors in origination and progress of acute leukemia in children

Thesis provides theoretical summarization and new approach in revealing of predisposition to AML and ALL in children with predicting the disease course and management optimizing through complex implementation of clinical/laboratory, genealogical, dermatoglyphic, immune-genetic and molecular-genetic assays. Rating scale and diagnostic index of the AL development according to dermatoglyphic data are originally invented. Set of informative genetically-bases risk factors of AL in children is for the first time defined and scientifically substantiated using the discriminative analysis of clinical history, clinical-genealogical examination results, constitutional peculiarities, disembryogenic stigma and dermatostructures accounting both with features of HLA-specificities distribution. Step-by-step screening algorithm is elaborated for revealing of hematological oncology predisposition in pediatric population. Initial clinical-laboratory features were linked to patients' genotype and phenotype peculiarities.Complex criteria for AL course prognostication in children are worked out aiming individual approach design in management and its efficacy improve.