Bityutsky V. Biotechnology of receiving of the complex antianemic preparations and their use in the correction of the adaptive systems of the young pigs' organisms in the postnatal ontogeny

Object - the biotechnology of complex antianaemic preparations receipt with antioxidant properties and their influence on the organism of piglings. Purpose - the purpose of work: constructing of new preventives for the prophylaxis of animal diseases - domestic complex metal-containing preparations with antioxidant characteristics, verification of efficiency of their action and approbation of the created preparations in production terms. Methods - biotechnological, physical and chemical, toxicological, biochemical, zootechnics, statistically-mathematical. Novelty - the biotechnology of new domestic complex injection antianaemic preparations receipt with antioxidant properties for the necessities of stock-raising is first developed and in the experiments the efficiency of their action is proved. It is defined that the developed preparations have antianaemic and antioxidant properties, conditioned by the complex of chelating essential microelements, which are in the composition of preparations, and differfrom inorganic salts by a natural form, high bioavailability and degree of metabolism in an organism. It is explored, that the cofactor providing of homeostatic mechanisms of antioxidant defence by the use of co-ordinating connections of biometals is instrumental in correction of the adaptive systems of organism of piglings in postnatal ontogenesis. It is defined that application of complex antianaemic preparations is economic an expedient measure for the prophylaxis of anaemia and oxidative stress at piglings in a period of postnatal development. A scientific novelty and actuality of developments is confirmed by four patents. Theoretical and practical results. Theoretical generalization and new decision of scientific problem, which consists in development of technology of receipt of complex antianaemic preparations, is resulted in dissertation. The got results deepen and extend modern presentations in relation to the processes of metabolism of metalcomplexes in a period of posnatal ontogenesis. According tothe results of researches the Technical terms of Ukraine on the Polimet preparations and Polimet-selen and options on their application are developed, approved and ratified. "Methodical recommendations for application of antianaemic preparations for correction of the adaptive systems of organism of piglings" and "Methodical recommendations for application of seleniumcontaining preparation with antioxidant properties for a prophylaxis and treatment of iron deficiency anaemia of piglings" are published. Degree of introduction. In the conditions of pig-breeding goods production complex CJSC( Closed Joint Stock Company) "Agro-soyuz" the introduction of the Polimet and Polimet-selen preparations and the comparison of their efficiency with preparation of a similar action Suiferon (Poland) is conducted. The results of researches testify that Polimet and Polimet-selen are effective remedies of prophylaxis of alimentary anaemia of piglings. It is defined that the Polimet and Polimet-selen preparations after efficiencyof action excel Suiferon preparation, they have economic and technological indicators superiority in the chart of prophylaxis of alimentary anaemia of piglings. The sphere of use - veterinary medicine and stock-raising.