Radchenko G. Criteria, determinate factors and reserves of effective treatment of patients with arterial hypertension according to data of prospective and retrospective observation

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0508U000450

Applicant for

Specialization

  • 14.01.11 - Кардіологія

01-07-2008

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

In the work there were proposed the theoretical generalization and new solution of the scientific and practical problem - increasing of effectiveness of treatment of the essential and renoparenchymal arterial hypertensive patients. Thesis is based on examination of 3287 hypertensive patients. Based on results of the retrospective and prospective observations it was found the main clinical, instrumental, patient's and physician's depending factors, that were connected with development of cardiovascular events, with onset or progression of target organ damage (heart, kidney, brain, vessels), with glucose and lipid metabolism disturbances, with poor blood pressure control and quality of life. There were substantiated the individual schemes of hypertension treatment depending on target organ damage evaluation and tissue insulin sensitivity. There were proposed the criteria of antihypertensive efficacy of treatment based on data of ambulatory blood pressure monitoring and bicycle exercise test.

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