Mamina Y. The elaboration and perfection of methods analysis of organic medicinal substances common investigation by conduct of legal - medical examinations

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0508U000606

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

31-10-2008

Specialized Academic Board

Д64.605.01

Essay

The dissertation is devoted to chemical-toxicological analysis of organic medicinal substances common investigation acid and basic character, the theoretical and experimental grounding of isolation of narcotical and toxic substances by chloroform from biological material. In the results the systematic investigation of organic medicinal substances common analysis have been elaborated the scheme of chemical-toxicological analysis of substances with using extraction by chloroform from liver of corpse, purifying extracts by hexane and in system chloroform-water from admixtures аnd Thin-layer Chromatography - method; identification and quantitative determination of substances with Gas-liquid Chromatography - method, Highly-effective liquid chromatography method, Extraction-photometric method with the use of indicators - methylorange, azocolour on base theophyllidin, derivative spectrophotometry and UV-spectrophotometry. The scheme of screening for conducting undirected analysis of biologic object (urine) on presence of narcotic and toxic substances of basic character with using HPLC- and GLC-analysis of ion-associates of substances with methylorange and azocolour on base theophyllidin has been worked out..

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