Moiseyenko Y. Dysadaptation mechanisms and complex pathogenic correction of the human's functional systems disorders in Antarctic

The medical-biological studies included the modern clinic-laboratory, functional, instrumental, biochemical, immunologic, genetic, statistical methods. Long influence of there factors brings to the adaptation processes disorders and dysadaptative development. It is shown that the mechanisms of dysadaptative disorders of oxygen-transport systems of the human organism at the long stay under the influence of the complex of extreme factors of Antarctic expedition developed on the background of the chain neurohumoural, neuroimmune, metabolic, celluar dysfunctions, which indicated on the presence of signs of long stressful condition (the stress-syndrome) that brings to adaptative mechanisms exhaustion of compensation and requires using the methods of correction. At the long stay of a man on the coast Antarctic station, there was revealed the seasonal dynamics of adaptative-dysadaptative rebuildings of regulative and oxygen-transport systems, there was revealed the presence of signs of stressful state and development of tissue hypoxia. It was shown the pathogenic mechanisms of development of dysadaptative disorders of integrative systems (change in cerebral electrogenesis, the activation of sympathoadrenal system, immune malresistance), respiratory, circulatory and hemic mechanisms of regulation of organism oxygen modes (the fall in efficiency and economy of the regulation mechanisms). It is shown the role of biorhythmologic and heliophysical factors of environment in development of dysadaptative disorders. It is for the first time fullfilled the genetic typization of the participants of Antarctic expedition on the presence of an allele polymorphism of specific genetic factor (hipoxia inducted factor - HIF-1). On the base of observation results on Antarctic station Academician Vernadskiy and clarification of the particularities of adaptative and dysadaptative rebuildings of human's functional systems at continuous stay in Antarctic is designed a complex pathogenic correction dysadaptative disorders among winterers with the use bioregulative, psychotherapeutic, physiotherapeutic, pharmacological and special facilities that raises the level of the maintenance of health and work capacity of specialists, working in Antarctic.